Solubility Enhancement of Poorly soluble Drugs by using Novel Techniques : A Comprehensive Review
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چکیده
منابع مشابه
Solubility Enhancement of Poorly Water Soluble Drugs: a Review
Among all newly discovered chemical entities about 40% drugs are lipophillic and fail to reach market due to their poor water solubility. Drug with poor water solubility cause slow dissolution rates, generally show erratic and incomplete absorption leading to low bioavailability when administered orally. Aqueous solubility of any therapeutically active substance is a key property, as it governs...
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Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...
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Orally administered drugs completely absorb only when they show fair solubility in gastric medium and shows good bioavailability. The solubility properties of drug play an important role in the process of formulation developments. Problem of solubility can be solved by different approaches. Each approach suffers with some limitations and advantages. Among all, complexation techinque has been em...
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Enhancement of solubility is one of the difficult tasks which become challenges in formulation development of orally administered drug with poor aqueous solubility. Poor water solubility of drugs often causes significant problems in producing formulations of sufficiently high bioavailability, preventing effective use of the drugs. 'Mixed-solvency ' concept is the phenomenon to increase the solu...
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Mechanochemical activation is a practical cogrinding operation used to obtain a solid dispersion of a poorly water soluble drug through changes in the solid state molecular aggregation of drug-carrier mixtures and the formation of noncovalent interactions (hydrogen bonds) between two crystalline solids such as a soluble carrier, lactose, and a poorly soluble drug, indomethacin, in order to impr...
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ژورنال
عنوان ژورنال: International Journal of PharmTech Research
سال: 2020
ISSN: 0974-4304,2455-9563
DOI: 10.20902/ijptr.2019.130211